Smooth Muscle-Protein Translocation and Tissue Function
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چکیده
منابع مشابه
Protein kinase C translocation in intact vascular smooth muscle strips.
Using intact muscle strips from the bovine carotid artery, the time course of translocation of protein kinase C (PKC) from the cytosol to the membrane fraction was measured in response to various agonists that induce contractile responses. PKC activity was assessed by Ca2+/phospholipid-dependent phosphorylation of histone. Exposure of the muscle strips to phorbol ester (12-deoxyphorbol 13-isobu...
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The subcellular distribution of protein kinase C was directly imaged in single living smooth muscle cells using a new fluorescent protein kinase C probe. The probe localized prominently to perinuclear organelles and, to a lesser extent, to the cytosol and surface membrane. The perinuclear signal did not detectably change over the time observed. The ratio between the surface membrane intensity a...
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BACKGROUND Halothane relaxes airway smooth muscle, in part, by decreasing the force produced for a given intracellular [Ca(2+)] (i.e., Ca(2+) sensitivity) during muscarinic stimulation, an effect produced by a decrease in regulatory myosin light-chain (rMLC) phosphorylation. The authors tested the hypothesis that halothane reduces rMLC phosphorylation during muscarinic stimulation at constant i...
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The control of force production in vascular smooth muscle is critical to the normal regulation of blood flow and pressure, and altered regulation is common to diseases such as hypertension, heart failure, and ischemia. A great deal has been learned about imbalances in vasoconstrictor and vasodilator signals, e.g., angiotensin, endothelin, norepinephrine, and nitric oxide, that regulate vascular...
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The gastrointestinal tract normally functions to move ingested food, in an organized fashion, from the oropharynx, through the stomach, small intestine and colon and into the rectum, from which it can be expelled. The primary function of the colon is to absorb water and electrolytes from the chyme delivered and, thus, determine the frequency, consistency, and volume of stools eliminated. The co...
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ژورنال
عنوان ژورنال: The Anatomical Record
سال: 2014
ISSN: 1932-8486
DOI: 10.1002/ar.22970